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Sharing our progress toward recovery

Research Summaries

Discover what the latest science from the RECOVER Initiative means for our ability to understand, diagnose, prevent, and treat Long COVID.

This page contains descriptions of findings from RECOVER research studies. These descriptions use plain language and a format that is easy to understand.

If you want to learn more about the scientific discoveries described here, you can also browse and search the complete list of RECOVER Publications.

6 Results

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6 Results

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Short Summary
Observational Pregnant Adult

Metz, TD; Reeder, HT; Clifton, RG; et al., Obstetrics & Gynecology

The RECOVER Initiative did a study to see how often pregnant women get Long COVID. The study looked at 1,502 pregnant participants. Participants took surveys about Long COVID symptoms around 10 months after they first got COVID. About 9% of them reported having Long COVID symptoms. The most common symptoms participants had were feeling very tired, especially after physical or mental activity, or being tired all the time. Some participants had stomach and gut problems. RECOVER researchers also found that people were more likely to get Long COVID if they needed extra oxygen while sick with COVID; had trouble paying bills; or had other health problems before COVID, such as obesity, depression, or anxiety. Future research will focus on whether having COVID while pregnant changes the chance of developing Long COVID. Researchers will compare this to people who got COVID when they were not pregnant.

Video
Observational Pediatric

Gross, RS; Thaweethai, T; Kleinman, LC; et al., JAMA

This RECOVER study is one of the first of its kind to look at Long COVID symptoms in children across age groups. Researchers for this study also developed a new research tool to help identify children who were most likely to have Long COVID. The study asked about prolonged or long-lasting symptoms in both school-age children (ages 6 to 11 years old) and teenagers (ages 12 to 17 years old) and compared these symptoms between those with and without a history of a COVID infection. The symptoms that were most likely to identify school-age children with Long COVID were trouble with memory or focusing, back or neck pain, stomach pain, headache, fears, refusing to go to school, skin rashes, trouble sleeping, nausea or vomiting, and lightheadedness or dizziness. The symptoms that were most likely to identify teenagers with Long COVID included change or loss of smell or taste, bone, muscle or joint pain, back or neck pain, feeling tired all day or after walking, having low energy, trouble with memory or focusing, headache, and lightheadedness or dizziness. These study findings show Long COVID symptoms can affect almost every organ system in the body. It also showed that while many of the symptoms between the two age groups were similar, there were differences. Understanding why these differences occur can help create future Long COVID treatments for children that are age-group specific. Read the Research Q&A

Short Summary
Observational Pediatric

Gross, RS; Thaweethai, T; Rosenzweig, EB; et. al.RECOVER-Pediatric Consortium, PLOS ONE

A COVID-19 infection can lead to new symptoms or symptoms that do not go away. This condition is called Long COVID. RECOVER researchers are working to answer questions about Long COVID in children. To do this, they are studying over 15,000 children and their caregivers in the US to understand how common Long COVID is in children and their caregivers; how the body changes when someone has Long COVID; what makes some people more likely to develop Long COVID, such as where a person lives and their age, race, and sex; and what happens in the body that might cause Long COVID. This paper is important because it can show other scientists how to do their own research on Long COVID in children.

Short Summary
Observational Pregnant Adult

Metz, TD; Clifton, RG; Gallagher, R; et. al.; RECOVER Initiative, PLOS ONE

A COVID-19 infection can lead to new symptoms, or symptoms that do not go away. This condition is called Long COVID. RECOVER researchers are working to answer questions about Long COVID in pregnant people. To do this, they are studying 2,300 pregnant people and their babies in the US to understand how often pregnant people get Long COVID; how the body changes when someone has Long COVID; what makes some people more likely to develop Long COVID, such as where a person lives and their age, race, and sex; and what happens in the body that might cause Long COVID. RECOVER researchers are also studying how COVID during pregnancy affects child development. This paper is important because it can show other scientists how to do their own research on Long COVID in pregnant people.

Short Summary
Observational Adult

Horwitz, LI; Thaweethai, T; Brosnahan, SB; et al., PLOS ONE

A COVID-19 infection can lead to new symptoms or symptoms that do not go away. This condition is called Long COVID. RECOVER researchers are working to answer questions about Long COVID in adults. To do this, they are studying over 12,000 adults in the US to understand how common Long COVID is in adults; how the body changes when someone has Long COVID; what makes some people more likely to develop Long COVID, such as where a person lives and their age, race, and sex; and what happens in the body that might cause Long COVID. This paper is important because it can show other scientists how to do their own research on Long COVID in adults.

Research Summary
Observational Adult

Thaweethai, T; Jolley, SE; Karlson, EW; et al., JAMA

RECOVER researchers used data from the RECOVER observational cohort study in adults ages 18 and over. They compared symptoms reported in surveys by participants who did and did not have COVID.

Researchers found 37 symptoms that participants who had COVID reported more often after having COVID compared to participants who never had COVID. 12 of these symptoms could identify participants with Long COVID, including feeling tired and unwell after activity, feeling weak and tired (fatigue), and brain fog. A definition of Long COVID based on symptoms is important for future research, including to find treatments. Read the Research Q&A

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