About RECOVER

Taking a united approach toward recovery

A man, a woman, and an a connected person icon

Together we can learn more. The more voices contributing to the RECOVER Initiative, the more meaningful and inclusive the answers will be to understanding, treating, and preventing the long-term effects of COVID.

This national effort brings together scientists, clinicians, patients, and caregivers to take on a critical problem: recovery from the long-term effects of COVID.

Many voices. One goal. Meaningful answers.

Progress is happening and what's being accomplished is historic in scale and scientific innovation.

39M+

People with a SARS-CoV-2 infection in the US ... and counting

10%-30%

Preliminary estimate of the percentage of people infected with SARS-CoV-2 who will experience PASC

100+

Number of researchers involved in RECOVER

200+

Estimated number of RECOVER research clinical sites

RECOVER Research Questions:

What does recovery from SARS-CoV-2 infection look like among different groups?
How many people continue to have symptoms after acute infection?
How many people develop new symptoms after acute infection?
What causes these health effects?
Why do some people develop these health effects while others do not?
Does SARS-CoV-2 infection trigger changes in the body that increase the risk of other conditions, such as chronic lung, heart, or brain disorders?

Recover Together

Progress takes the best science.

The RECOVER Initiative is applying a meta-cohort study design to pool participants in combination with real-world data to propel multiple research studies forward.

Each study contributes distinct types of knowledge to advance understanding of post-acute sequelae of SARS-CoV-2 (PASC), is unified through main protocols, and involves multiple cohorts—or groups of people. With research sites across the country, the RECOVER Cohort anticipates enrolling adults, children and their caregivers, and pregnant women and their newborn infants. In addition, research will include using electronic health records.

A map of the United States with the message: Recover sites coming soon

RECOVER is Powered by Collaboration

Progress takes teamwork.

Many of the country's leading researchers have come together to form a brilliant team known as the RECOVER Consortium.

Given RECOVER's national scale and scope, the Consortium prioritizes harmonization as a key strategy to getting meaningful answers. In spring 2021, more than 30 institutions were awarded funds to participate in the development of—and successfully completed—main protocols to achieve harmonization. Patients and representatives of patient organizations joined in this critical step for RECOVER.

A set of main protocols:

  • Serves as the Consortium's playbook by enabling researchers to speak the same language, use the same methods, and examine the same types of data.
  • Allows data collected from many participants by different research groups to be compared and analyzed, helping to speed up the research process and provide more meaningful, reliable findings.

With RECOVER's main protocols completed, additional funding was awarded in fall 2021 establishing the RECOVER Consortium and providing the infrastructure to advance RECOVER's research studies.

A woman, a girl, and a man

Progress takes participants.

The RECOVER Initiative is inclusive by design and will involve a pool of tens of thousands of participants across multiple cohorts. Creating a research initiative that ensures a diverse group of participants reflecting the Nation's population is essential so that the results and findings can be broadly applied.

A meta-cohort study design pools multiple groups of people together that share a common characteristic. In this case, participants will be people who have experienced an infection of SARS-CoV-2, the virus that causes COVID-19. To serve as a participant in RECOVER research studies, different studies will have different requirements. RECOVER will also seek to enroll participants without SARS-CoV-2 infection to serve as a comparison group.

NIH National Institutes of Health leading to Biorepository Core, Data Resource Core, Clinical Science Core, and Administrative Coordinating Center; which leads to the RECOVER Consortium into Research Infrastructure then RECOVER Participants. All of this makes up the Research StudiesNIH National Institutes of Health leading to Biorepository Core, Data Resource Core, Clinical Science Core, and Administrative Coordinating Center; which leads to the RECOVER Consortium into Research Infrastructure then RECOVER Participants. All of this makes up the Research Studies

Research Awardees

The RECOVER Consortium represents a national study population of diverse research volunteers. It will support studies that are part of an intensive effort to learn about the recovery process following infection with SARS-CoV-2 and why some individuals have prolonged symptoms.

The RECOVER Cohort will include awardees across multiple focus areas, including adults, pediatrics, pregnant participants, tissue pathology (autopsy) studies, and real-world data.

Check back at a later date for additional awardees

  • Brigham and Women's Hospital
  • Case Western Reserve Univ School of Medicine
  • Howard Univ College of Medicine
  • Univ of Alabama at Birmingham Heersink School of Medicine
  • Univ of Arizona College of Medicine - Tucson
  • Univ of Illinois Hospital & Health Sciences System
  • Univ of Texas Health Science Center
  • Univ of Utah Health
  • West Virginia Univ Health Sciences
  • Emory University

Check back at a later date for additional awardees

  • Arkansas Children's Research Institute
  • Children's Hospital Los Angeles
  • Rhode Island Hospital
  • Rutgers Robert Wood Johnson Medical School

Check back at a later date for additional awardees

  • Univ of Utah Health

Check back at a later date for additional awardees

  • Brigham and Women's Hospital
  • CVPath Institute

Check back at a later date for additional awardees

Infrastructure Awardees

The three RECOVER Cores and the Administrative Coordinating Center facilitate and provide the RECOVER Initiative's infrastructure or organizational framework around which the research is conducted.

Together, their primary role is to build and support the RECOVER Initiative, its participant pool and team of investigators, and to ensure that data are standardized and shared among researchers and with the public.

Build the RECOVER Consortium—a group of lead investigators among the research awardees—to harmonize and coordinate data, develop methods for monitoring protocols, and guide communication and engagement with key stakeholders such as patients and clinicians.

Help enable tracking and searchability across all data sources and provide expertise in statistical analyses and data standardization, access, and sharing.

Receive, manage, and make available to researchers a diverse range of biospecimens obtained from RECOVER research studies.

Provide oversight and monitoring support in addition to communication, work group, protocol development, and implementation support.

FAQs

Researchers leading RECOVER Cohort studies have a broad range of expertise and will work together to identify the core set of information that will be collected and the tests that will be done on all RECOVER Cohort participants.

Potential data sources include clinical exams, health records, autopsy reports, and a diverse range of biospecimens. Data repositories will receive and store the various types of data collected and analyzed. These data and biospecimens will be made available to the research community to support further studies of PASC.

Funding announcements and requests for information describing additional research activities are expected in the months ahead. For example, clinical trials will test approaches for treating or preventing the long-term health effects of SARS-CoV-2 infection.

Study findings will be shared. Key features of the initiative include the long-term follow-up of patients and adapting research strategies as our understanding of PASC grows.

RECOVER may help us learn how people recover from viral infections in general. It may also help improve our understanding of other post-viral syndromes, such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and autoimmune diseases—conditions in which the body's immune system attacks healthy cells.

The best way to protect yourself against these effects is to get vaccinated and encourage your friends, family, and neighbors to get the vaccine. Find a COVID-19 vaccination site near you at Vaccines.gov.

Sign up to be alerted when studies open for enrollment. Clinical trials will launch in the next several months.

RECOVER research isn't available yet. Stay tuned to this website and sign up for email updates.

In the meantime, RECOVER's Clinical Science Core is using the National Library of Medicine's LitCovid resource. This is a curated literature hub for tracking up-to-date scientific information about COVID-19. Articles are updated daily and categorized by research topic, including Long COVID, and geographic location for easier access.