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Have questions about the long-term health effects of the virus? Start by learning about PASC.Share to Raise Awareness
RECOVER, an initiative from the National Institutes of Health (NIH), seeks to understand, prevent, and treat PASC, including Long COVID. PASC is a term scientists are using to study the potential consequences of a SARS-CoV-2 infection.
Progress takes people like you.
Learning comes from listening. Your life and experiences help frame NIH's research questions. The scientists and health professionals involved in new RECOVER studies are committed to engaging people whose health is adversely affected by this virus.
Progress takes inclusion.
COVID-19 has affected millions. While many people are suffering, people of color have been hit the hardest.
"NIH deeply appreciates the contributions of patients who have not fully recovered from SARS-CoV-2 infection and who have offered their experiences and insights.... We now ask the patient, medical, and scientific communities to come together to help us understand the long-term effects of SARS-CoV-2 infection."Francis Collins, MD, PhD
Director, National Institutes of Health
Risk for COVID-19 Hospitalization by Race/Ethnicity Compared to White, Non-Hispanic Persons
- American Indian or Alaska Native
- Hispanic or Latino
- Black or African American
Progress takes coordinated action.
Progress takes coordinated action.
Teamwork is at the heart of RECOVER. Many people, groups, and organizations are working together through a collection of studies referred to as the SARS-CoV-2 Recovery Cohort. These studies include diverse groups of people, including adults and children.
The studies will include participants from:
- Long COVID clinics that treat people with ongoing symptoms
- NIH-supported COVID-19 studies and networks
- Established NIH-supported studies of other diseases and conditions
- Other settings
What is PASC?
SARS-CoV-2 is a virus that can infect the body, referred to as a SARS-CoV-2 infection. Recovery from SARS-CoV-2 infection can vary from person to person:
Acute Infection: Most people recover quickly from acute SARS-CoV-2 infection. Reported symptoms from people with acute infection range from mild to severe. In some cases, this is diagnosed as COVID-19. Other people do not experience any symptoms of infection. People who do not experience symptoms can also be diagnosed with SARS-CoV-2 infection.
For some people, symptoms last weeks or months after the acute infection has passed. This is often referred to as Long COVID.
For other people, new symptoms may appear after the acute infection has passed whether or not they had symptoms during the acute infection.
Post-acute experience: Together, these and other health effects of the virus are called post-acute sequelae of SARS-CoV-2 infection, or PASC. PASC refers to what happens after the acute infection with the virus and is relevant whether a person has been diagnosed with COVID-19 or not. Even if someone did not experience symptoms, PASC is still relevant because there could be consequences after acute infection.
Post-acute experience: Together, these and other health effects of the virus are called post-acute sequelae of SARS-CoV-2 infection, or PASC. PASC refers to what happens after the acute infection of the virus and is relevant whether a person has been diagnosed with COVID-19 or not. Even if someone did not experience symptoms, PASC is still relevant because there could be consequences after acute infection.
Given the number of adults and children who have been or will experience SARS-CoV-2 infection, the public health impact of PASC could be very large.
Hosted by the NIH, this meeting will examine the long-term effects of SARS-CoV-2 infection on the brain and possible interactions with other infections such as HIV. A panel of scientists will discuss related research gaps and priorities.
July 14–15, 2021
Shares what PASC is, who is affected, and what NIH is doing to address it
What is NIH doing to address the ongoing health effects of SARS-CoV-2 infection?
Researchers leading Recovery Cohort studies have a broad range of expertise and will work together to identify the core set of information that will be collected and the tests that will be done on all Recovery Cohort participants.
Potential data sources include clinical exams, health records, autopsy reports, and a diverse range of biospecimens. Data repositories will receive and store the various types of data collected and analyzed. These data and biospecimens will be made available to the research community to support further studies of PASC.
How will RECOVER change over time?
Funding announcements and requests for information describing additional research activities are expected in the months ahead. For example, clinical trials will test approaches for treating or preventing the long-term health effects of SARS-CoV-2 infection.
Study findings will be shared. Key features of the initiative include the long-term follow-up of patients and adapting research strategies as our understanding of PASC grows.
It's estimated that millions of Americans suffer from post-viral syndromes other than PASC. Will RECOVER help them?
RECOVER may help us learn how people recover from viral infections in general. It may also help improve our understanding of other post-viral syndromes, such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and autoimmune diseases—conditions in which the body's immune system attacks healthy cells.
What can I do to help prevent the long-term effects of SARS-CoV-2 infection?
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To ensure this research is informed by patients' experiences, RECOVER will engage with people who have experienced SARS-CoV-2 infection to hear their voices and stories.
What types of updates would you like to receive?General updates about RECOVER and latest research on PASC and Long COVID Related research funding, training, and technical assistance announcements