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Understanding of PASC (post-acute sequelae of SARS-CoV-2), including Long COVID, is constantly evolving as new research is funded and studies begin. Stay informed by reading the latest news, watching videos, and participating in upcoming events.

Latest News and Updates


RECOVER program takes first steps in advancing toward clinical trials to better understand Long COVID

The NIH RECOVER initiative is preparing several clinical trials to evaluate treatments to improve symptoms related to post-acute sequelae of SARS-CoV-2 infection (PASC) or Long COVID. A trial protocol recently posted to ClinicalTrials.gov is in the final stages of development and approvals, and is expected to begin enrolling participants in early 2023. This trial is one of several that will test a variety of treatments for Long COVID.

Each trial will examine a treatment that targets one of five specific clusters of symptoms and their potential causes. Through RECOVER study questionnaires, surveys, and discussions with people who have Long COVID, these symptoms were considered most burdensome, most important to address, and the priorities for trial protocols under development.

The protocols for each trial were developed with patients and experts in these symptom areas. RECOVER researchers will also continue to engage patients, caregivers, and community representatives to better understand the impact of Long COVID on different groups.

More information about the clinical trials will be posted on recoverCOVID.org as it becomes available.

Read the full announcement for more details.

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  • recoverCOVID.org
  • October 31, 2022

Duke Selected as RECOVER Clinical Trials Data Coordinating Center

The Duke Clinical Research Institute (DCRI) has been named the Clinical Trials Data Coordinating Center (DCC) for the NIH RECOVER Initiative. DCRI will partner with the RECOVER Administrative Coordinating Center (ACC), based at RTI International.

Together, the ACC and DCC will oversee the study’s clinical trial infrastructure, establish a patient registry, simultaneously launch prevention and therapeutic multi-intervention studies for both adults and children, and work to accelerate the clinical trial process.

The DCC will align with other, existing COVID research projects, including the RECOVER Consortium and the NIH-funded ACTIV (Accelerating COVID-19 Therapeutic Interventions and Vaccines) studies, to help advance the science on the health effects of COVID.

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  • DCRI.org
  • August 2, 2022

RECOVER Research Awards

RECOVER has awarded over $37 million in funding for more than 40 research projects. These studies will quickly advance what we know about how COVID affects different body tissues and organs.

The studies will tell us more about how the many different symptoms develop in people who have had COVID. We’ll also learn about what causes the long-term effects of COVID, known as Long COVID.

The research awards include:

  • More funding to researchers whose current studies show promise to quickly advance understanding of what causes lasting symptoms in Long COVID.
  • New funding to teams of RECOVER researchers from different specialty areas to support further analysis of tissue samples and data collected in current RECOVER studies.

View the awardees

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  • recoverCOVID.org
  • August 12, 2022

NIH Director’s Blog: Using AI to Advance Understanding of Long COVID Syndrome

One of the most puzzling aspects of the COVID-19 pandemic is understanding why some people who have short-term COVID later develop new symptoms. Or they may continue to have symptoms while also developing new ones. These Long COVID symptoms can vary a lot from person to person, which makes it hard to understand why some people are more likely to have Long COVID. In this blog post, NIH Director Lawrence Tabak, DDS, PhD, discusses an important new RECOVER study published in The Lancet Digital Health that used artificial intelligence computer models to help unravel this mystery.

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  • NIH Director's Blog
  • June 7, 2022

RECOVER Publication: Scientists use Electronic Health Records and Machine Learning to Better Define Long COVID

In a study published in The Lancet Digital Health, Pfaff and colleagues used electronic health record (EHR) data to find more than 100,000 likely cases of Long COVID in an EHR database of more than 13 million people.

The authors examined information from nearly 98,000 COVID-19 patients on demographics, use of health care services, medications, and diagnoses in the National COVID Cohort Collaborative (N3C) database—a national, centralized public database led by NIH’s National Center for Advancing Translational Sciences (NCATS). They used those data with information from nearly 600 patients at Long COVID clinics to create machine learning (ML) computer models that could identify potential Long COVID patients.

The ML models proved to be accurate and identified about 100,000 people in the database whose profiles matched those of people with Long COVID. The study findings will help researchers understand the characteristics and risk factors linked to Long COVID diagnosis and will also help identify potential Long COVID patients for clinical trials. As more data sources are identified, these models can be improved and adapted based on study needs.

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  • NIH.gov
  • May 16, 2022

RECOVER Adult Study Protocol Available

The full RECOVER research protocol, or study plan, for adults taking part in RECOVER studies is now available. The study protocol serves as the RECOVER research playbook, enabling researchers to speak the same language, use the same methods, and examine the same types of data. We are finished planning the adult study protocol, but the protocol may change over time as we learn more. If the protocol is updated, we will share it on the RECOVER website, recoverCOVID.org. A version of the protocol in easy-to-understand language will be available soon.

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  • recoverCOVID.org
  • March 28, 2022

NIH Builds Large Nationwide Study Population of Tens of Thousands to Support Research on Long-term Effects of COVID-19

The NIH awarded nearly $470 million to build a national study population of diverse research volunteers and support large-scale studies on the long-term effects of COVID-19. The NIH Researching COVID to Enhance Recovery (RECOVER) Initiative made the parent award to New York University (NYU) Langone Health, New York City, which will make multiple subawards to more than 100 researchers at more than 30 institutions and serves as the RECOVER Clinical Science Core.

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  • NIH.gov
  • September 15, 2021

Breakthrough Infections in Vaccinated People Less Likely to Cause "Long COVID"

The evidence shows that vaccines make a big difference in protecting individuals and communities against infection and severe illness from SARS-CoV-2 infection. New research shows another important reason to get the vaccine. In the event of a breakthrough COVID infection, people who are fully vaccinated are less likely to develop Long COVID. The symptoms of Long COVID include fatigue, brain fog, muscle pain, and other debilitating symptoms that can last for months after recovery from an initial infection, whether the person had symptoms or not. Though we still have much to learn about PASC, including Long COVID, vaccines offer a very effective way to protect against COVID-19 and reduce the chances of getting Long COVID if people do get infected.

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  • NIH Director's Blog
  • September 14, 2021

COVID Long-Haulers Get Disability Civil Rights Protections

On July 26, 2021, the Federal government released guidance that people with PASC and Long COVID can be protected under the Americans with Disabilities Act. PASC and Long COVID will be considered a disability if the condition or its symptoms “substantially limit” major life activities, such as work or school. Read this fact sheet for more details.

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  • The White House
  • July 26, 2021

NIH Infrastructure Awards to Support Research on Post-COVID Conditions

NIH recently announced the Core resource awards that will provide critical infrastructure for new research studies under the RECOVER Initiative. NYU Langone Health was awarded over $14 million in support of the Clinical Science Core, which will build the RECOVER Consortium; harmonize and coordinate data within the Consortium; and develop methods for monitoring protocols, including recruitment, data quality, and safety measures to identify adverse events. The Biostatistics Center at Massachusetts General Hospital was awarded more than $8.6 million in support of the Data Resource Core, which will help enable tracking and searchability of results across all sources of data, from clinical studies to electronic health records.

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  • NIH.gov
  • June 10, 2021

Videos and Presentations


RECOVER Research Review (R3) SEMINAR SERIES on a background showing the RECOVER COVID virus icon

The goal of the R3 Seminar Series is to catalyze a shared understanding of the research of the scientific stakeholder community within the RECOVER consortium. Working and learning together, while keeping each other up to date on the latest insights to accelerate discovery. Some R3 sessions will also inform the public about RECOVER and other research on PASC. All sessions will be recorded and posted to recoverCOVID.org.

Visit the R3 Seminar Page to View Upcoming Seminars
  • NIH
  • Ongoing series began March 1, 2022

RECOVER January Listening Session Recording Available: Understanding Long COVID Across Communities of Color (January 21, 2022)

This event facilitated discussion between RECOVER researchers and members of organizations that represent and support communities of color to better understand levels of awareness of Long COVID in these communities. It also informed opportunities to promote diverse and inclusive participation in the RECOVER Initiative studies. Dr. Andrea Lerner from the NIH and Dr. Natasha Williams from NYU Langone Health cohosted the event alongside the moderator, Dr. James E.K. Hildreth of Meharry Medical College.

View the recording.

A transcript of the event is available here (PDF, 136 KB).

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  • NIH
  • January 21, 2022

PASC Seminar Series Sponsored by the Foundation for the National Institutes of Health

The Foundation for the National Institutes of Health sponsors the ACTIV seminar series, which is organized in partnership with Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) and the National Heart, Lung, and Blood Institute. ACTIV brings together leading experts on PASC to share their published or ongoing research on different aspects of the disease. The sessions are recorded and published, and you can watch past sessions at the ACTIV link above. Some past ACTIV presentations include:

  • Barriers to Improving PASC Outcomes – Dr. Michelle Gong, MD, MS, Albert Einstein College of Medicine, October 4, 2021
  • Probing Disease Mechanisms of Long COVID – Dr. Akiko Iwasaki, PhD, Yale University School of Medicine, October 28, 2021
  • Neurological Symptoms During and After COVID-19 – Dr. Shelli Farhadian, MD, PhD, Yale University School of Medicine, November 4, 2021
  • Observations on Long COVID through an ME/CFS Lens – Peter Rowe, MD, Johns Hopkins Medicine, January 14, 2022
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  • Foundation for the National Institutes of Health
  • Ongoing series began October 4, 2021

RECOVER Launches the Live Series: First Session Recording

The first RECOVER Live Series event, Inside the RECOVER Initiative, a Conversation with Dr. Stuart Katz of NYU Langone Health, was held on November 30, 2021. Dr. Katz shared information from experts working on the RECOVER Initiative about what is being done to understand, prevent, and treat PASC, including Long COVID. This event also included a live Q&A session, where people viewing online posted questions for Dr. Katz. View the recording.

A transcript of the event is available here (PDF, 106 KB).

  • NIH.gov
  • November 30, 2021

Understanding Long COVID: The Unseen Public Health Crisis

Understanding Long COVID: The Unseen Public Health Crisis

Harvard T.H. Chan School of Public Health hosted a free, online discussion on November 19, 2021 that brought together clinicians, researchers, policy experts, and Long COVID patients.

  • Harvard T.H. School of Public Health
  • November 19, 2021

RECOVER Initiative Stakeholder Briefing

RECOVER Initiative Stakeholder Briefing

In coordination with the RECOVER Initiative announcement on September 15, 2021, the NIH invited RECOVER Initiative stakeholders to join NIH leadership in a public briefing to discuss the announcement and address questions from the community. The briefing was led by Dr. Amy Patterson (NIH – NHLBI), with Dr. Stuart Katz (NYU, Principal Investigator of the RECOVER Clinical Science Core), Emily Taylor (Solve M.E.), and Dr. Lenora Johnson (NIH – NHLBI), who addressed more than 550 virtual attendees and answered questions about the RECOVER Initiative.

A transcript of the event is available here (PDF, 137 KB).

  • NIH.gov
  • September 15, 2021

Long-term COVID Patient Engagement: Best Practices Informed By Patients' Experiences Seeking Medical Care

Long-term COVID Patient Engagement: Best Practices Informed By Patients' Experiences Seeking Medical Care

During COVID-19 Grand Rounds hosted by the NIH Health Care Systems Research Collaboratory on July 23, 2021, representatives of Survivor Corps presented their efforts to conduct research with their online community of 170,000 individuals affected by COVID-19. Survivor Corps is a grassroots movement using its members' collective experience to build a repository of data sets and research tools to support COVID-19 research, including studies on PASC and Long COVID.

  • NIH Collaboratory
  • July 23, 2021

Neurologic and Psychiatric Effects of SARS-CoV-2 Infection

Neurologic and Psychiatric Effects of SARS-CoV-2 Infection

Hosted by the NIH, this meeting looked at the long-term effects of SARS-CoV-2 infection on the brain and possible interactions with other infections, such as HIV. Watch the recording to hear scientists discuss related research gaps and priorities.

  • NIH.gov
  • July 14-15, 2021

Treating Long COVID: Clinician Experience with Post-Acute COVID-19 Care

Treating Long COVID: Clinician Experience with Post-Acute COVID-19 Care

In this webinar, clinicians share their experiences with treating Long COVID and establishing clinics that provide care for patients with the long-term effects of SARS-CoV-2 infection.

  • CDC.gov
  • February 1, 2021

A hand holding a microphoneMedia Inquiries

Are you a member of the media or press? Please direct inquiries to the RECOVER@nih.gov inbox. Please place "MEDIA INQUIRY" in the subject line.

Find a study site near you at:
studies.recoverCOVID.org
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