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RECOVER

Our understanding of Long COVID is constantly evolving with new research findings. Stay informed by reading the latest news, watching videos, and participating in upcoming events.

Latest News and Updates


NIH opens Long COVID trials to evaluate treatments for autonomic nervous system dysfunction

RECOVER is now enrolling adults in two new clinical trials. These trials will study the safety and effectiveness of at least three potential treatments for symptoms like fast heart rate, dizziness, and fatigue caused by damage to the autonomic nervous system, which controls automatic body functions like heartbeat and blood pressure.

Read the full news release.

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  • recoverCOVID.org
  • March 12, 2024

NIH to bolster RECOVER Long COVID research efforts through infusion of $515 million

To bolster Long COVID research efforts, NIH is investing an additional $515 million over the next four years into the RECOVER Initiative, a nationwide research program to fully understand, diagnose and treat Long COVID.

Read the full news release.

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  • recoverCOVID.org
  • February 13, 2023

Leadership Q&A: NIH to bolster RECOVER Long COVID research efforts

NIH RECOVER Initiative Co-Leaders Gary Gibbons, M.D., Walter Koroshetz, M.D., and Jeanne Marrazzo, M.D., M.P.H. share progress, and answer questions about investing an additional $515 million and what it means for the Initiative.

Read the full Q&A.

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  • recoverCOVID.org
  • February 13, 2024

Now Available: Dataset for “Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection”

RECOVER research data are now available from the JAMA publication, "Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection", published on May 25, 2023. The data are available as a de-identified datafile consistent with the NIH data sharing policy. Individuals who would like to access the datafile must review the Data Use/Sharing Principles and Code of Conduct for the RECOVER Data Gateway and complete the datafile request form. Once the form is complete, requests will be reviewed and additional information to obtain the data will be provided to requestors.

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  • recoverCOVID.org
  • October 31, 2022

Changes in the body provide clues for the development of Long COVID

A research team that includes RECOVER researchers found changes in the immune system of people with Long COVID. In a study supported by NIH and the RECOVER Initiative, researchers tested blood drawn from 268 people with and without Long COVID. The resulting data suggest that 3 types of biological changes may contribute to Long COVID and require further investigation:

  • Low levels of cortisol, a hormone that helps control the body's response to stress and reduces inflammation
  • High levels of viral antigens, or cells that fight viral infections
  • Dormant or inactive viruses, such as the Epstein-Barr virus (EBV), that become active again

These discoveries help describe changes in the bodies of people with Long COVID and could help inform tests and treatments for Long COVID. The journal Nature has published the study’s complete findings.

Read the full news release.

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  • NIH.gov
  • October 3, 2022

RECOVER-NEURO enrolls first participant in trial

RECOVER-NEURO, a clinical trial examining how different interventions can help people with symptoms of cognitive dysfunction related to long COVID, has enrolled its first participant. RECOVER-NEURO is part of the RECOVER initiative, and all RECOVER clinical trials are coordinated by the Duke Clinical Research Institute (DCRI). This Phase 2 trial will focus on possible treatments to improve working memory, attention, executive functions, and information processing speed for people who have Long COVID.

Read the full news release.

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  • recoverCOVID.org
  • September 5, 2023

RECOVER-VITAL enrolls first participant in trial

RECOVER-VITAL, a clinical trial examining if the antiviral PAXLOVID (nirmatrelvir and ritonavir) improves symptoms for people who have long COVID, has enrolled its first participant. RECOVER-VITAL is part of the RECOVER initiative and all RECOVER clinical trials are coordinated by the Duke Clinical Research Institute (DCRI). Researchers believe that viral persistence (when the virus that causes COVID-19 stays in the body and causes damage to organs or the immune system to not function properly) may cause long COVID symptoms.

Read the full news release.

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  • recoverCOVID.org
  • July 31, 2023

NIH launches long COVID clinical trials through RECOVER Initiative, opening enrollment

The National Institutes of Health has launched and is opening enrollment for phase 2 clinical trials that will evaluate at least four potential treatments for long COVID, with additional clinical trials to test at least seven more treatments expected in the coming months. Treatments will include drugs, biologics, medical devices, and other therapies. The trials are designed to evaluate multiple treatments simultaneously to identify more swiftly those that are effective. The trials will focus on several of the symptoms described as most burdensome by people experiencing long COVID.

Read the full news release.

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  • recoverCOVID.org
  • July 31, 2023

RECOVER Research Q&A: RECOVER “First Look” Adult Cohort Study

On May 25, 2023, RECOVER shared its “first look” into findings from the adult cohort study. The study, titled “Development of a Definition of Post-Acute Sequelae of SARS-CoV-2 Infection” was peer-reviewed and published in the Journal of the American Medical Association (JAMA) . As a result of widespread interest in the study, a Q&A was developed to answer some of the most asked questions about this research and why it matters.

Read the Research Q&A.

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  • recoverCOVID.org
  • June 9, 2023

RECOVER study provides scientists with deeper insight into Long COVID

Study identifies most common Long COVID symptoms with aim of improving future diagnostics and treatment

Initial findings from a RECOVER study of nearly 10,000 Americans, many of whom had COVID-19, have uncovered new details about Long COVID. Researchers found in the study, published in JAMA , that certain Long COVID symptoms occurred together, and defined four symptom patterns or clusters that have a range of impacts on patient health. The research team also found that Long COVID was more common and severe in study participants infected before the 2021 Omicron variant.

Read the full news release.

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  • recoverCOVID.org
  • May 25, 2023

Videos and Presentations


RECOVER Research Review (R3) SEMINAR SERIES on a background showing the RECOVER COVID virus icon

The goal of the R3 Seminar Series is to share the RECOVER Initiative’s research findings with researchers and the public. Researchers work and learn together, keeping each other up to date on the latest research insights. Some R3 seminars also inform the public about other research on Long COVID. We record all R3 sessions and post the recordings and seminar Q&As to the R3 Seminar page.

Visit the R3 Seminar Page to View Upcoming Seminars
  • NIH
  • Ongoing series began March 1, 2022

NIH VideoCast Recording: NIH RECOVER Initiative: Early Findings and Other Emerging Long COVID Science

As part of the NIH-FDA COVID-19 Scientific Interest Group (SIG) Seminar Series, Clinton Wright M.D., M.S., Senior Oversight Committee Co-Chair for the RECOVER Initiative, presented the webinar NIH RECOVER: Early Findings and Other Emerging Long COVID Science on September 14, 2023.

Dr. Wright summarized early Long COVID research, which has shown that people with Long COVID experience symptoms that affect many different organ systems in the body. He stressed the importance of collaboration between researchers with different scientific backgrounds sharing their research findings to better predict, prevent, and treat Long COVID. Dr. Wright provided an overview of the RECOVER initiative, discussed the patient-centered focus of RECOVER, and reviewed the RECOVER scientific aims and research components. He presented early findings from the RECOVER Initiative and other Long COVID research that is informing clinical trials.

View the recording.

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  • NIH
  • September 14, 2023

NIH VideoCast Recording: Highlights of Pandemic Related Successes in Tribal Communities Webinar

NIH RECOVER, the Community Engagement Alliance (CEAL), and the Tribal Health Research Office (THRO) co-sponsored the Highlights of Pandemic Related Successes in Tribal Communities Webinar, held on Wednesday, December 7, 2022. This event was tailored specifically for research team members across RECOVER, CEAL, and NIH to spotlight successful approaches used during the COVID-19 pandemic to engage members of Tribal Communities. Experts from the Center for Indigenous Health and the Indian Health Service shared how they met the needs and priorities of these communities, overcame barriers to vaccination, and developed best practices for engagement around COVID-19 related research that might be applicable to other research efforts and public health matters of importance. The webinar also featured a panel discussion and a live Q&A session, which were moderated by Mose A Herne, MPH, MS, THRO Senior Advisor.

View the recording.

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  • NIH
  • December 7, 2022

RECOVER Electronic Health Records (EHR) Study Compares Risks of Heart Problems after COVID Infection and mRNA COVID Vaccination

Researchers from RECOVER and the National Patient-Centered Clinical Research Network (PCORnet) compared the risk of heart problems after COVID infection and after mRNA COVID vaccination. They used EHR data from 40 health care systems representing more than 15 million people, aged 5 years or older. The study compared people of similar age, gender, and number of vaccine doses to see what increased the risk of heart problems.

The study found that the risk of heart problems after getting an mRNA COVID vaccine was very low for people of all ages and genders. Also, the risk of having heart problems after having COVID was significantly higher than after getting an mRNA COVID vaccine.

These findings support the continued use of the recommended mRNA COVID-19 vaccine for all eligible people aged 5 or older. See this recent study in the CDC’s Morbidity and Mortality Weekly Report (MMWR) .

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  • NIH
  • April 1, 2022

RECOVER January Listening Session Recording Available: Understanding Long COVID Across Communities of Color (January 21, 2022)

This event facilitated discussion between RECOVER researchers and members of organizations that represent and support communities of color to better understand levels of awareness of Long COVID in these communities. It also informed opportunities to promote diverse and inclusive participation in the RECOVER Initiative studies. Dr. Andrea Lerner from the NIH and Dr. Natasha Williams from NYU Langone Health cohosted the event alongside the moderator, Dr. James E.K. Hildreth of Meharry Medical College.

View the recording.

A transcript of the event is available here (PDF, 136 KB).

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  • NIH
  • January 21, 2022

PASC Seminar Series Sponsored by the Foundation for the National Institutes of Health

The Foundation for the National Institutes of Health sponsors the ACTIV seminar series, which is organized in partnership with Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) and the National Heart, Lung, and Blood Institute. ACTIV brings together leading experts on PASC to share their published or ongoing research on different aspects of the disease. The sessions are recorded and published, and you can watch past sessions at the ACTIV link above. Some past ACTIV presentations include:

  • Barriers to Improving PASC Outcomes – Dr. Michelle Gong, MD, MS, Albert Einstein College of Medicine, October 4, 2021
  • Probing Disease Mechanisms of Long COVID – Dr. Akiko Iwasaki, PhD, Yale University School of Medicine, October 28, 2021
  • Neurological Symptoms During and After COVID-19 – Dr. Shelli Farhadian, MD, PhD, Yale University School of Medicine, November 4, 2021
  • Observations on Long COVID through an ME/CFS Lens – Peter Rowe, MD, Johns Hopkins Medicine, January 14, 2022
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  • Foundation for the National Institutes of Health
  • Ongoing series began October 4, 2021

RECOVER Launches the Live Series: First Session Recording

The first RECOVER Live Series event, Inside the RECOVER Initiative, a Conversation with Dr. Stuart Katz of NYU Langone Health, was held on November 30, 2021. Dr. Katz shared information from experts working on the RECOVER Initiative about what is being done to understand, prevent, and treat PASC, including Long COVID. This event also included a live Q&A session, where people viewing online posted questions for Dr. Katz. View the recording.

A transcript of the event is available here (PDF, 106 KB).

  • NIH.gov
  • November 30, 2021

Understanding Long COVID: The Unseen Public Health Crisis

Understanding Long COVID: The Unseen Public Health Crisis

Harvard T.H. Chan School of Public Health hosted a free, online discussion on November 19, 2021 that brought together clinicians, researchers, policy experts, and Long COVID patients.

  • Harvard T.H. School of Public Health
  • November 19, 2021

RECOVER Initiative Stakeholder Briefing

RECOVER Initiative Stakeholder Briefing

In coordination with the RECOVER Initiative announcement on September 15, 2021, the NIH invited RECOVER Initiative stakeholders to join NIH leadership in a public briefing to discuss the announcement and address questions from the community. The briefing was led by Dr. Amy Patterson (NIH – NHLBI), with Dr. Stuart Katz (NYU, Principal Investigator of the RECOVER Clinical Science Core), Emily Taylor (Solve M.E.), and Dr. Lenora Johnson (NIH – NHLBI), who addressed more than 550 virtual attendees and answered questions about the RECOVER Initiative.

A transcript of the event is available here (PDF, 137 KB).

  • NIH.gov
  • September 15, 2021

Long-term COVID Patient Engagement: Best Practices Informed By Patients' Experiences Seeking Medical Care

Long-term COVID Patient Engagement: Best Practices Informed By Patients' Experiences Seeking Medical Care

During COVID-19 Grand Rounds hosted by the NIH Health Care Systems Research Collaboratory on July 23, 2021, representatives of Survivor Corps presented their efforts to conduct research with their online community of 170,000 individuals affected by COVID-19. Survivor Corps is a grassroots movement using its members' collective experience to build a repository of data sets and research tools to support COVID-19 research, including studies on PASC and Long COVID.

  • NIH Collaboratory
  • July 23, 2021

Neurologic and Psychiatric Effects of SARS-CoV-2 Infection

Neurologic and Psychiatric Effects of SARS-CoV-2 Infection

Hosted by the NIH, this meeting looked at the long-term effects of SARS-CoV-2 infection on the brain and possible interactions with other infections, such as HIV. Watch the recording to hear scientists discuss related research gaps and priorities.

  • NIH.gov
  • July 14-15, 2021

Treating Long COVID: Clinician Experience with Post-Acute COVID-19 Care

Treating Long COVID: Clinician Experience with Post-Acute COVID-19 Care

In this webinar, clinicians share their experiences with treating Long COVID and establishing clinics that provide care for patients with the long-term effects of SARS-CoV-2 infection.

  • CDC.gov
  • February 1, 2021

Media Inquiries

Are you a member of the media or press? Please direct inquiries to the RECOVER@nih.gov inbox. Please place "MEDIA INQUIRY" in your subject line.

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