Continuing the search for answers

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NIH funding helps advance the understanding, prevention, and treatment of post-acute sequalae of SARS-CoV-2 (PASC), including Long COVID. The RECOVER Initiative supports a set of complementary areas of research through solicitations or Research Opportunity Announcements (ROAs).

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Want to learn more about NIH's response to COVID-19? Read the NIH-wide COVID-19 Strategic Plan.

Current RECOVER Funding Opportunities

Description: The National Institutes of Health (NIH) is asking for applications proposing clinical trials in people over 18 years old for the prevention and/or treatment of PASC as part of the NIH RECOVER Initiative. The NIH is seeking proposals for clinical trials testing a range of interventions and using diverse methods to address symptoms/symptom clusters and the underlying mechanisms of the pathobiology of PASC. An important component of the RECOVER Initiative is the active engagement and contribution of people suffering with PASC, as well as their caregivers, in the development of the research program. As such, trial proposals should reflect community and patient engagement. Funding of the projects will utilize NIH’s Other Transaction Authority (OTA), which offers flexibility and the ability to engage partners in collaborative innovation and problem solving. Please direct all inquiries to: NHLBI_OTA@mail.nih.gov.

A technical assistance webinar for this ROA was held on Friday, May 6th, 2022.

Watch the Technical Assistance Webinar

Slides from Technical Assistance Webinar (PDF, 1.01 MB)

Summary of FAQs Received by NIH about the Clinical Trials ROA (PDF, 174 KB)

Description: The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is planning a new research initiative to characterize the onset, clinical course, and physiology of new-onset diabetes after having COVID-19. The FOA will invite investigator-initiated applications to establish a controlled longitudinal observational multicenter clinical study of individuals who developed diabetes following SARS-CoV-2 infection. One award will be made. The FOA will utilize the U01 activity code. It is expected to be published in late spring 2022, with an expected due date for applications in late fall 2022.

Closed RECOVER Funding Opportunities

Description: This NOSI was issued to encourage investigators with expertise in PASC pathobiology to apply for supplemental funding to leverage current awards to rapidly advance understanding of the pathobiological underpinnings of PASC, including the pathogenic mechanisms responsible for persistent symptoms after acute infection and/or pathology in multiple organs/systems that has, or will, lead to clinically significant health problems. This opportunity was open to all NIH investigators that met the eligibility criteria.

Resources: Answers to frequently asked questions (FAQs) were developed, including questions about currently funded status, multiple submissions, information about basic requirements, turnaround times, qualifying research studies, and areas of expertise.

Description: This ROA solicited applications to adapt and support a scalable, configurable, and integrated Mobile Health Platform to provide RECOVER studies with customized mobile apps and to enable the secure collection of PASC digital health measures.

Resources: Answers to frequently asked questions (FAQs) were developed, including the initiative's scope, application submission, ROA requirements, and budget. A Technical Assistance Workshop was held on July 15, 2021, with the presentation slides made publicly available.

Description: This ROA solicited applications for the following: a Digital Health Data Repository; an Imaging Data Repository; a Pathology Data Repository; and a Clinical and Observational Data Repository for the RECOVER Initiative.

Resources: Answers to frequently asked questions (FAQs) were developed, including the initiative's scope, application submission, ROA requirements, and budget. A Technical Assistance Workshop was held on July 15, 2021, with the presentation slides made publicly available.

Description: This ROA included three components: a Clinical Science Core to develop and implement master protocols; a Data Resource Core to oversee the collection and sharing of PASC-related data; and a PASC Biorepository Core to establish and maintain a central data repository.

Resources: Answers to frequently asked questions (FAQs) were developed, including the initiative's scope, application submission, ROA requirements, and budget. A Technical Assistance Workshop was held on March 1, 2021, with the presentation slides made publicly available.

Description: This ROA comprised two studies to leverage new and existing processes and data. One study includes people who are newly diagnosed with SARS-CoV-2 and the other study includes people who have recovered and have new or persistent symptoms.

Resources: Answers to frequently asked questions (FAQs) were developed, including the initiative's scope, application submission, ROA requirements, and budget. A Technical Assistance Workshop was held on March 1, 2021, with the presentation slides made publicly available.

Find Studies near you at:
studies.recovercovid.org
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