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Sharing science to understand Long COVID
RECOVER Research Review (R3) Seminar Series
The goal of the R3 Seminar Series is to share the RECOVER Initiative’s research findings with researchers and the public. These seminars accelerate scientific discovery by allowing experts to share their latest insights on Long COVID and related conditions. Some R3 sessions also inform the public about other research on Long COVID. You can find recordings of all R3 Seminar sessions in the Previous Seminars section below.
Understanding metformin use and Long COVID and ME/CFS following COVID-19 infection: Insights from two studies
RECOVER investigators will present findings about the association between metformin use and the incidence of Long COVID using the EHR-based cohort study. The speakers will also present findings about the incidence and prevalence of myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) following COVID-19 infection using the adult observational cohort study.
During the June 13th RECOVER Research Review (R3) Seminar, RECOVER researchers described a symptom-based approach for defining long COVID in adults from a study published in JAMA. This presentation is based upon some early findings from the RECOVER Adult Observational Cohort study.
During the May 9th RECOVER Research Review (R3) Seminar, researchers from PEDSnet presented RECOVER research about PASC in children and adolescents using EHR data. The panelists discussed the clinical features and burden of pediatric PASC and explained how research findings could be used to develop a definition of long COVID in children.
During the April 25th RECOVER Research Review (R3) Seminar, researchers presented the status of RECOVER clinical trial protocols. Presenters discussed the landscape of Long COVID's clinical trials and the development of RECOVER's upcoming clinical trials.
During the April 11th RECOVER Research Review (R3) Seminar, researchers explored the mechanistic pathways of PASC, focusing on how the virus that causes COVID-19 led to long-term effects. Presenters discussed the molecular basis of Long COVID, including olfactory impairment, plasma proteomics, and the role of T-cell chronotypes in autoimmunity.
During the March 14th RECOVER Research Review (R3) Seminar, researchers presented on how to characterize PASC in adults using electronic health record (EHR) data. The seminar covered the RECOVER EHR cohort study, the National COVID Cohort Collaborative (N3C), and two different methods to identify PASC subphenotypes based on symptom presentation.
During the January 24th RECOVER Research Review (R3) Seminar, researchers presented on viral persistence and viral reservoirs in PASC. Presenters discussed current understandings of how the virus that causes COVID-19 can persist and form reservoirs in the body, leading to long-term effects.
During the January 10th RECOVER Research Review (R3) Seminar, researchers provided a high-level overview of the mechanistic pathways of PASC. Presenters covered immunology, pathology, and viral reservoirs, exploring how these factors contribute to long-term health issues following COVID-19 infection.
During the December 13th RECOVER Research Review (R3) Seminar, researchers presented on the vascular pathophysiology of PASC, exploring how blood vessel dysfunction might contribute to long-term effects following COVID-19 infection.
During the November 8th RECOVER Research Review (R3) Seminar, researchers presented their understanding of the biomarkers of PASC. Presenters discussed the need for biomarkers, early immunological findings, ultrasensitive viral antigen measurements, and markers of fungal translocation.
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