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Sharing science to understand Long COVID
RECOVER Research Review (R3) Seminar Series
The goal of the R3 Seminar Series is to share the RECOVER Initiative’s research findings with researchers and the public. These seminars accelerate scientific discovery by allowing experts to share their latest insights on Long COVID and related conditions. Some R3 sessions also inform the public about other research on Long COVID. You can find recordings of all R3 Seminar sessions in the Previous Seminars section below.
Ethical considerations for enrolling “invested parties” in large-scale clinical studies: Insights from the RECOVER Initiative
The speakers will discuss ethical considerations for enrolling individuals who have a direct role in the study – such as investigators, research staff, or patient, caregiver and community Representatives - as study participants. Drawing from experience with the RECOVER initiative, they will present an ethical framework for enrolling “invested parties” in research.
During the February 13th RECOVER Research Review (R3) Seminar, several pathobiology study awardees presented about the mechanisms of neurological (brain and nervous system) symptoms of Long COVID.
During the January 23rd RECOVER Research Review (R3) Seminar, researchers presented on the progress and future directions of the RECOVER Initiative. Speakers from the RECOVER adult, pediatric, and autopsy cohorts provided an overview of the progress to date, what is in the pipeline and the ultimate promise of RECOVER for each of the cohorts. A review of the current state of the science of Long COVID and gaps in knowledge was also discussed.
During the December 12th RECOVER Research Review (R3) Seminar, panelists discussed immune features of Long COVID, the relationship between Long COVID and metabolism (chemical reactions that provide the body with energy), and impact of acute and Long COVID on the brain.
During the November 14th RECOVER Research Review (R3) Seminar, researchers discussed multiple different biological mechanisms likely underlaid PASC manifestations. This seminar explored several prominent mechanisms that were areas of active study, including persistent SARS-CoV-2 viral reservoirs, abnormal immune system activation, and effects on metabolic pathways.
During the July 11th RECOVER Research Review (R3) Seminar, presenters discussed the disparities and environmental risk factors in PASC using EHR Insights. This seminar explored racial and ethnic disparities as well as community-level environmental factors in PASC among adults.
During the June 13th RECOVER Research Review (R3) Seminar, RECOVER researchers described a symptom-based approach for defining long COVID in adults from a study published in JAMA. This presentation is based upon some early findings from the RECOVER Adult Observational Cohort study.
During the May 9th RECOVER Research Review (R3) Seminar, researchers from PEDSnet presented RECOVER research about PASC in children and adolescents using EHR data. The panelists discussed the clinical features and burden of pediatric PASC and explained how research findings could be used to develop a definition of long COVID in children.
During the April 25th RECOVER Research Review (R3) Seminar, researchers presented the status of RECOVER clinical trial protocols. Presenters discussed the landscape of Long COVID's clinical trials and the development of RECOVER's upcoming clinical trials.
During the April 11th RECOVER Research Review (R3) Seminar, researchers explored the mechanistic pathways of PASC, focusing on how the virus that causes COVID-19 led to long-term effects. Presenters discussed the molecular basis of Long COVID, including olfactory impairment, plasma proteomics, and the role of T-cell chronotypes in autoimmunity.
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