The neurobiology of Long COVID

Monje, M; Iwasaki, A, Neuron

Epub ahead of print indicates that the article has completed the peer review process and has been published online in advance of the actual print journal issue being released.

View epub on PubMed

Published

November 2022

Journal

Neuron

Abstract

Persistent neurological and neuropsychiatric symptoms affect a substantial fraction of people after COVID-19 and represent a major component of the post-acute COVID-19 syndrome, also known as long COVID. Here, we review what is understood about the pathobiology of post-acute COVID-19 impact on the CNS and discuss possible neurobiological underpinnings of the cognitive symptoms affecting COVID-19 survivors. We propose the chief mechanisms that may contribute to this emerging neurological health crisis.

Authors

Michelle Monje, Akiko Iwasaki

Keywords

COVID-19; EBV; HSV; PAISs; SARS-CoV-2; astrocytes; autoimmunity; blood-brain-barrier; cognitive impairment; hippocampal neurogenesis; long COVID; microglia; microvascular disease; myelin; post-acute infection syndromes