The neurobiology of Long COVID

• November 2022
• Neuron

Publication Details

DOI: 10.1016/j.neuron.2022.10.006

Abstract

Persistent neurological and neuropsychiatric symptoms affect a substantial fraction of people after COVID-19 and represent a major component of the post-acute COVID-19 syndrome, also known as long COVID. Here, we review what is understood about the pathobiology of post-acute COVID-19 impact on the CNS and discuss possible neurobiological underpinnings of the cognitive symptoms affecting COVID-19 survivors. We propose the chief mechanisms that may contribute to this emerging neurological health crisis.

Authors

Michelle Monje, Akiko Iwasaki

Keywords

COVID-19; EBV; HSV; PAISs; SARS-CoV-2; astrocytes; autoimmunity; blood-brain-barrier; cognitive impairment; hippocampal neurogenesis; long COVID; microglia; microvascular disease; myelin; post-acute infection syndromes