Investigations of Increased Cardiovascular Risk and Coagulation in Survivors of COVID-19 including those with PASC: Role of Oxidative Lipids and Glucose Metabolism

Introduction: COVID infection and subsequent development of post-acute sequelae of SARS-CoV-2 (PASC) have been associated with increased levels of oxidative lipids and with enhanced systemic inflammation. There is very little known about the role of oxidized LDL in PASC, and in particular in the increased risk of cardiovascular disease, altered glucose metabolism, and hypercoagulability.

Objective: The goal of this application is twofold: to study the effect of lipids and specifically oxidized LDL, on immune activation, inflammation, and hypercoagulability in PASC, and to assess the effect of COVID infection on glucose intolerance and its risk factors and relationship to immune activation.

Methods: We will use data and samples from the RECOVER population who enrolled as uninfected and later became COVID-infected during the RECOVER study, and as such we will be able to compare the endpoints of interest between the pre-COVID and post-COVID evaluations in this group of participants.

Results: Pending.

Conclusion/Discussion: Pending.

Key Topics:

• Chronic immune dysfunction
• Clinical manifestations of chronic viral infections, biological pathways, immune-autoimmune disorders, systems, organs, or diseases
• Studies of vascular injury, thrombosis, and other potential mechanisms of Long COVID