Maintenance and Incidence of ME/CFS following Mono

Introduction: Our proposed work will explore immune and metabolic markers of those with PASC and compare it with our work on ME/CFS.

Objective: To determine immunologic and metabolomic risk factors for the development of post-acute sequelae of SARS-CoV-2 (PASC) following SARS-CoV-2 infection and ME/CFS following IM.

Methods: The PIs have also successfully completed a series of NIH supported epidemiologic and prospective studies of ME/CFS, most recently, the development of ME/CFS following IM in college students. We have frozen serum and plasma from students at all three stages and viably frozen white blood cells from students at stages 2 and 3. We will compare this ME/CFS sample in 18-19-year-olds to a sample of similar aged youth with PASC. To determine immunologic and metabolomic risk factors for the development of PASC following SARS-CoV-2 infection and ME/CFS following IM. We hypothesize that altered host immune and metabolomic profiles will be associated with post-viral fatigue following primary EBV and SARS-CoV-2 infection, in contrast to healthy controls.

Results: Pending.

Conclusion/Discussion: Pending.

Key Topics:

• Comparative studies of Long COVID with other post-viral and post-infectious syndromes