RECOVER Systems Biology Program

Introduction: The generation of the multi-omic (proteomic, metabolomic, transcriptomic, epigenomic, and genomic) data from adult and pediatric samples to enable a broad range of scientific studies.

Objective: To characterize the molecular underpinnings of post-acute sequelae of SARS-CoV-2 (PASC) and its subtypes in adults and children via multi-omic data generation.

Methods: To characterize the molecular underpinnings of PASC and its subtypes via multi-omic data generation from biospecimens collected from RECOVER Adult and Pediatric cohorts to : 1) identify the mechanisms of disease development and progression; 2) discover and characterize molecular disease subtypes; 3) enable accurate prediction of the disease course; and 4) lead to novel diagnostic and/or prognostic biomarkers and potential therapeutic interventions to improve the clinical course of PASC.

Results: Pending.

Conclusion/Discussion: Pending.

Key Topics:

• Assay and in vitro studies to gain mechanistic insights
• Biomarker, in-depth phenotyping assays and in vitro studies using tissue and other biospecimens
• Clinical assessment and pathogenesis of clinical manifestations
• Collaborative and systems biology approaches
• Long COVID and other chronic conditions
• Long COVID in special populations
• Therapeutic targets and drug development
• Viral persistence/reactivation