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About the Initiative

Taking a united approach toward recovery

What is RECOVER?

The RECOVER Initiative is a patient-centered, integrated, adaptive research network
RECOVER's goal is to understand, treat, and prevent Long COVID. RECOVER uses an integrated study design and takes a diverse, inclusive, and patient-centered approach to achieve this goal.

Diverse and Inclusive

RECOVER studies involve tens of thousands of people from all walks of life, hundreds of research investigators, and millions of electronic health records (EHRs). Findings from each RECOVER study type inform the other RECOVER studies to accelerate our understanding of Long COVID.


Patients, their families, and caregivers play critical roles in RECOVER research. By sharing their experiences and perspectives, they help us understand why Long COVID impacts people in different ways.

Adaptive Research Network

RECOVER’s mission is to address the widespread and diverse impacts of Long COVID. Taking a multidisciplinary, large-scale approach allows us to address the complexity of Long COVID and find solutions for everyone.

Integrated Study Design

RECOVER research findings are compatible across all RECOVER studies. Study protocols are the same for each study type at each RECOVER research site. In this way, RECOVER researchers can learn from each other’s research and get more answers about Long COVID more quickly.

Scientific Aims


Understand the range of recovery from Long COVID and changes it can cause in our bodies over time.


Define risk factors, understand the number of people getting Long COVID, and determine whether there are specific, different Long COVID types.


Study how Long COVID changes over time and how those changes may relate to other illnesses.


Identify possible treatments for Long COVID symptoms.

How Does it Work?

Research Components & Information Exchange

RECOVER is unprecedented in its size and scope. It includes the world’s most comprehensive and diverse cohort of Long COVID patients. RECOVER researchers are studying a collection of more than 60 million EHRs for insights about those who received care during the pandemic. RECOVER is also enrolling 20,000 adults, pregnant people, and children in cohort studies and leveraging existing community-based studies to include 60,000 more people.

Graphic showing the interaction of the RECOVER project's Research Components and Information Exchange.

Patients, Caregivers, Community Representatives, Governance Committees, and Work Groups

These groups all contribute to how RECOVER works.

All Data Shared

Four concepts interact to integrate the information gained from the groups into the overall RECOVER project.

Learning from People

This includes information from Tissue Pathology/Autopsy, as well as Cohort- and Community-based Study Groups.

Clinical Science

This includes information from Pathobiology.

Real World Data

This includes information from Electronic Health Records and the Digital Health Program.

Studying Treatments

This receives data and information from the other components and integrates that knowledge gained into Clinical Trials.

Patients, Caregivers, Community Representatives, Governance Committees, and Work Groups all contribute to how RECOVER works.

Learning from People

  • Cohort and Community-based Studies
  • Autopsy/Tissue Pathology Studies

Clinical Science

  • Pathobiology

Real World Data

  • Electronic Health Records (EHR)
  • Digital Health Program

Studying Treatments

  • Clinical Trials

All Data Shared

Data is shared between the different types of RECOVER research to inform clinical trials.

RECOVER is combining data from 4 different types of studies to understand what’s happening in the body when people have Long COVID. These data include insights from studies of people and of real-world health data, the results of more than 40 pathobiology studies examining more than 50 types of tissues, and the results of autopsies and tissue pathology studies.

RECOVER is also using the findings from each of these study types and from patient experiences to inform the development of integrated platform clinical trials. The clinical trials will identify possible treatments to help with Long COVID symptoms.

Explore the different RECOVER research components

Progress to Date

Created the world's most comprehensive and diverse cohort of Long COVID patients.

New discoveries about Long COVID symptoms, who has Long COVID, why some people are more at risk of getting Long COVID, and how Long COVID can affect people differently.

Added real-time health data from wearable sensors to real-world data collected from 60 million EHRs.

Gained insights from cohort studies, which met enrollment goals for adults, to inform clinical trials.

Launched clinical trials to develop interventions and evaluate treatments for symptoms of Long COVID.

Portraits of people living with long-COVID.

What's to Come

More progress toward RECOVER’s goal to understand, diagnose, prevent, and treat Long COVID. Explore research findings in publications

Sharing data with researchers beyond RECOVER. Continue to share findings in R3 Seminar series. See upcoming R3 seminars

Compare and validate EHR findings with other real-world data.

Continued involvement of patients, caregivers, and community members in the research process. Learn about Community Participation in RECOVER

Patient registry to continue involvement of participants in RECOVER.

Meet cohort study enrollment goals for pregnant people, babies, children, and adolescents to gain more insights.

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