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Sharing science to find answers

Find RECOVER Publications

Researchers within the RECOVER Initiative share their progress to understand, treat, and prevent Long COVID through research publications. Follow the latest science from RECOVER’s research studies below.

Visit the Research Summaries page to learn about RECOVER’s Long COVID research in a format that’s easy to understand.

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53 Results

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53 Results

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Pathobiology Adult
Lercher, A; Cheong, JG; Jiang, C; et. al., bioRxiv
Information
Caution: Preprints are preliminary reports of work that have not been certified by peer review. They should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Published:
Journal: bioRxiv
Abstract: Pathogen encounter results in long-lasting epigenetic imprinting that shapes diseases caused by heterologous pathogens. The breadth of this innate immune memory is of particular interest in the context of respiratory pathogens with increased pandemic potential and wide-ranging impact on global health. Here, we investigated epigenetic imprinting across cell lineages in a disease relevant murine model of SARS-CoV-2 recovery. Past SARS-CoV-2 infection resulted in increased chromatin accessibility… Continue reading
Authors: Alexander Lercher, Jin-Gyu Cheong, Chenyang Jiang, Hans-Heinrich Hoffmann, Alison W Ashbrook, Yue S Yin, Corrine Quirk, Emma J DeGrace, Luis Chiriboga, Brad R Rosenberg, Steven Z Josefowicz, Charles M Rice
Keywords: Not available
Pathobiology Adult
Farhadian, SF; Reisert, HD; McAlpine, L; et. al., JAMA Network Open
Published:
Journal: JAMA Network Open
Abstract: Not available
Authors: Shelli F Farhadian, Hailey D Reisert, Lindsay McAlpine, Jennifer Chiarella, Priya Kosana, Jennifer Yoon, Serena Spudich
Keywords: Humans; Neuroinflammatory Diseases; Self Report; COVID-19; Brain
EHR Adult
Hill, EL; Mehta, HB; Sharma, S; et. al., BMC Public Health
Published:
Journal: BMC Public Health
Abstract: More than one-third of individuals experience post-acute sequelae of SARS-CoV-2 infection (PASC, which includes long-COVID). The objective is to identify risk factors associated with PASC/long-COVID diagnosis. This was a retrospective case-control study including 31 health systems in the United States from the National COVID Cohort Collaborative (N3C). 8,325 individuals with PASC (defined by the presence of the International Classification of Diseases, version 10 code U09.9 or a long-COVID… Continue reading
Authors: Elaine L Hill, Hemalkumar B Mehta, Suchetha Sharma, Klint Mane, Sharad Kumar Singh, Catherine Xie, Emily Cathey, Johanna Loomba, Seth Russell, Heidi Spratt, Peter E DeWitt, Nariman Ammar, Charisse Madlock-Brown, Donald Brown, Julie A McMurry, Christopher G Chute, Melissa A Haendel, Richard Moffitt, Emily R Pfaff, Tellen D Bennett; N3C Consortium; RECOVER Consortium
Keywords: COVID-19; Long-COVID; PASC; Post-acute sequelae of SARS-CoV-2; Risk factors
Pathobiology Adult
VanElzakker, MB; Bues, HF; Brusaferri, L; et. al., bioRxiv
Information
Caution: Preprints are preliminary reports of work that have not been certified by peer review. They should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Published:
Journal: bioRxiv
Abstract: The COVID-19 pandemic caused by SARS-CoV-2 has triggered a consequential public health crisis of post-acute sequelae of COVID-19 (PASC), sometimes referred to as long COVID. The mechanisms of the heterogeneous persistent symptoms and signs that comprise PASC are under investigation, and several studies have pointed to the central nervous and vascular systems as being potential sites of dysfunction. In the current study, we recruited individuals with PASC with diverse symptoms, and examined the… Continue reading
Authors: Michael B VanElzakker, Hannah F Bues, Ludovica Brusaferri, Minhae Kim, Deena Saadi, Eva-Maria Ratai, Darin D Dougherty, Marco L Loggia
Keywords: COVID-19; Long COVID pathogenesis; brain inflammation; cardiovascular; fibrinogen; glia; microglia; neuroimaging; positron emission tomography
Review Adult
Kim, C; Chen, B; Mohandas, S; et. al., eLife
Published:
Journal: eLife
Abstract: The NIH-funded RECOVER study is collecting clinical data on patients who experience a SARS-CoV-2 infection. As patient representatives of the RECOVER Initiative's Mechanistic Pathways task force, we offer our perspectives on patient motivations for partnering with researchers to obtain results from mechanistic studies. We emphasize the challenges of balancing urgency with scientific rigor. We recognize the importance of such partnerships in addressing post-acute sequelae of SARS-CoV-2… Continue reading
Authors: C Kim, Benjamin Chen, Sindhu Mohandas, Jalees Rehman, Zaki A Sherif, K Coombs, RECOVER Mechanistic Pathways Task Force, RECOVER Initiative
Keywords: Humans; Post-Acute COVID-19 Syndrome; COVID-19; SARS-CoV-2; Disease Progression; Biomedical Research
Pathobiology Adult
Klein, J; Wood, J; Jaycox, J; et. al., Nature
Information
Epub ahead of print indicates that the article has completed the peer review process and has been published online in advance of the actual print journal issue being released.
Published:
Journal: Nature
Abstract: Post-acute infection syndromes (PAIS) may develop after acute viral disease. Infection with SARS-CoV-2 can result in the development of a PAIS known as "Long COVID" (LC). Individuals with LC frequently report unremitting fatigue, post-exertional malaise, and a variety of cognitive and autonomic dysfunctions; however, the biological processes associated with the development and persistence of these symptoms are unclear. Here, 273 individuals with or without LC were enrolled in a cross-sectional… Continue reading
Authors: Jon Klein, Jamie Wood, Jillian Jaycox, Rahul M Dhodapkar, Peiwen Lu, Jeff R Gehlhausen, Alexandra Tabachnikova, Kerrie Greene, Laura Tabacof, Amyn A Malik, Valter Silva Monteiro, Julio Silva, Kathy Kamath, Minlu Zhang, Abhilash Dhal, Isabel M Ott, Gabrielee Valle, Mario Peña-Hernandez, Tianyang Mao, Bornali Bhattacharjee, Takehiro Takahashi, Carolina Lucas, Eric Song, Dayna Mccarthy, Erica Breyman, Jenna Tosto-Mancuso, Yile Dai, Emily Perotti, Koray Akduman, Tiffany J Tzeng, Lan Xu, Anna C Geraghty, Michelle Monje, Inci Yildirim, John Shon, Ruslan Medzhitov, Denyse Lutchmansingh, Jennifer D Possick, Naftali Kaminski, Saad B Omer, Harlan M Krumholz, Leying Guan, Charles S Dela Cruz, David van Dijk, Aaron M Ring, David Putrino, Akiko Iwasaki
Keywords: Not available
EHR Adult
Summary
L Mandel, H; Colleen, G; Abedian, S; et. al., Sleep
Published:
Journal: Sleep
Abstract: Obstructive sleep apnea (OSA) has been associated with more severe acute coronavirus disease-2019 (COVID-19) outcomes. We assessed OSA as a potential risk factor for Post-Acute Sequelae of SARS-CoV-2 (PASC). We assessed the impact of preexisting OSA on the risk for probable PASC in adults and children using electronic health record data from multiple research networks. Three research networks within the REsearching COVID to Enhance Recovery initiative (PCORnet Adult, PCORnet Pediatric, and the… Continue reading
Authors: Hannah L Mandel, Gunnar Colleen, Sajjad Abedian, Nariman Ammar, L Charles Bailey, Tellen D Bennett, M Daniel Brannock, Shari B Brosnahan, Yu Chen, Christopher G Chute, Jasmin Divers, Michael D Evans, Melissa Haendel, Margaret A Hall, Kathryn Hirabayashi, Mady Hornig, Stuart D Katz, Ana C Krieger, Johanna Loomba, Vitaly Lorman, Diego R Mazzotti, Julie McMurry, Richard A Moffitt, Nathan M Pajor, Emily Pfaff, Jeff Radwell, Hanieh Razzaghi, Susan Redline, Elle Seibert, Anisha Sekar, Suchetha Sharma, Tanayott Thaweethai, Mark G Weiner, Yun Jae Yoo, Andrea Zhou, Lorna E Thorpe
Keywords: Not available
Short Summary

Researchers wanted to see if patients who had difficulty breathing while sleeping (Obstructive Sleep Apnea; OSA) were at higher risk for developing Long COVID compared to people without OSA. By comparing the electronic health record (EHR) data of COVID positive patients, researchers looked at the risk of developing Long COVID in patients with and without a previous diagnosis of OSA.

Researchers found that adults with a previous diagnosis of OSA had an increased chance of developing Long COVID when compared to patients that did not have a previous diagnosis of OSA.

Pathobiology Adult
Cheong, JG; Ravishankar, A; Sharma, S; et. al., Cell
Information
Epub ahead of print indicates that the article has completed the peer review process and has been published online in advance of the actual print journal issue being released.
Published:
Journal: Cell
Abstract: Inflammation can trigger lasting phenotypes in immune and non-immune cells. Whether and how human infections and associated inflammation can form innate immune memory in hematopoietic stem and progenitor cells (HSPC) has remained unclear. We found that circulating HSPC, enriched from peripheral blood, captured the diversity of bone marrow HSPC, enabling investigation of their epigenomic reprogramming following coronavirus disease 2019 (COVID-19). Alterations in innate immune phenotypes and… Continue reading
Authors: Jin-Gyu Cheong, Arjun Ravishankar, Siddhartha Sharma, Christopher N Parkhurst, Simon A Grassmann, Claire K Wingert, Paoline Laurent, Sai Ma, Lucinda Paddock, Isabella C Miranda, Emin Onur Karakaslar, Djamel Nehar-Belaid, Asa Thibodeau, Michael J Bale, Vinay K Kartha, Jim K Yee, Minh Y Mays, Chenyang Jiang, Andrew W Daman, Alexia Martinez de Paz, Dughan Ahimovic, Victor Ramos, Alexander Lercher, Erik Nielsen, Sergio Alvarez-Mulett, Ling Zheng, Andrew Earl, Alisha Yallowitz, Lexi Robbins, Elyse LaFond, Karissa L Weidman, Sabrina Racine-Brzostek, He S Yang, David R Price, Louise Leyre, André F Rendeiro, Hiranmayi Ravichandran, Junbum Kim, Alain C Borczuk, Charles M Rice, R Brad Jones, Edward J Schenck, Robert J Kaner, Amy Chadburn, Zhen Zhao, Virginia Pascual, Olivier Elemento, Robert E Schwartz, Jason D Buenrostro, Rachel E Niec, Franck J Barrat, Lindsay Lief, Joseph C Sun, Duygu Ucar, Steven Z Josefowicz
Keywords: COVID-19; IL-6; PASC; epigenetic memory; epigenome; hematopoietic stem and progenitor cells; monocytes; peripheral blood mononuclear cell progenitor input enrichment; post-acute sequelae SARS-CoV-2 infection; single-cell; trained immunity; transcriptome
Pathobiology Adult
Wilcox, DR; Rudmann, EA; Ye, E; et. al., AIDS
Information
Epub ahead of print indicates that the article has completed the peer review process and has been published online in advance of the actual print journal issue being released.
Published:
Journal: AIDS
Abstract: Data supporting dementia as a risk factor for coronavirus disease 2019 (COVID-19) mortality relied on ICD-10 codes, yet nearly 40% of individuals with probable dementia lack a formal diagnosis. Dementia coding is not well established for people with HIV (PWH), and its reliance may affect risk assessment.
Authors: Douglas R Wilcox, Emily A Rudmann, Elissa Ye, Ayush Noori, Colin Magdamo, Aayushee Jain, Haitham Alabsi, Brody Foy, Virginia A Triant, Gregory K Robbins, M Brandon Westover, Sudeshna Das, Shibani S Mukerji
Keywords: Humans; COVID-19/complications; SARS-CoV-2; COVID-19 Testing; Retrospective Studies; HIV Infections/complications; Risk Factors; Cognition; Dementia
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