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Sharing science to find answers

Find RECOVER Publications

Researchers within the RECOVER Initiative share their progress to understand, treat, and prevent Long COVID through research publications. Follow the latest science from RECOVER’s research studies below.

Visit the Research Summaries page to learn about RECOVER’s Long COVID research in a format that’s easy to understand.

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54 Results

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54 Results

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Pathobiology Adult
Farhadian, SF; Reisert, HD; McAlpine, L; et. al., JAMA Network Open
Published:
Journal: JAMA Network Open
Abstract: Not available
Authors: Shelli F Farhadian, Hailey D Reisert, Lindsay McAlpine, Jennifer Chiarella, Priya Kosana, Jennifer Yoon, Serena Spudich
Keywords: Humans; Neuroinflammatory Diseases; Self Report; COVID-19; Brain
Pathobiology Adult
Lercher, A; Cheong, JG; Jiang, C; et. al., bioRxiv
Information
Caution: Preprints are preliminary reports of work that have not been certified by peer review. They should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Published:
Journal: bioRxiv
Abstract: Pathogen encounter results in long-lasting epigenetic imprinting that shapes diseases caused by heterologous pathogens. The breadth of this innate immune memory is of particular interest in the context of respiratory pathogens with increased pandemic potential and wide-ranging impact on global health. Here, we investigated epigenetic imprinting across cell lineages in a disease relevant murine model of SARS-CoV-2 recovery. Past SARS-CoV-2 infection resulted in increased chromatin accessibility… Continue reading
Authors: Alexander Lercher, Jin-Gyu Cheong, Chenyang Jiang, Hans-Heinrich Hoffmann, Alison W Ashbrook, Yue S Yin, Corrine Quirk, Emma J DeGrace, Luis Chiriboga, Brad R Rosenberg, Steven Z Josefowicz, Charles M Rice
Keywords: Not available
EHR Pediatric
Rao, S; Jing, N; Liu, X; et. al., Scientific Reports
Published:
Journal: Scientific Reports
Abstract: Multi-system inflammatory syndrome in children (MIS-C) is a severe post-acute sequela of SARS-CoV-2 infection in children, and there is a critical need to unfold its highly heterogeneous disease patterns. Our objective was to characterize the illness spectrum of MIS-C for improved recognition and management. We conducted a retrospective cohort study using data from March 1, 2020-September 30, 2022, in 8 pediatric medical centers from PEDSnet. We included 1139 children hospitalized with MIS-C… Continue reading
Authors: Suchitra Rao, Naimin Jing, Xiaokang Liu, Vitaly Lorman, Mitchell Maltenfort, Julia Schuchard, Qiong Wu, Jiayi Tong, Hanieh Razzaghi, Asuncion Mejias, Grace M Lee, Nathan M Pajor, Grant S Schulert, Deepika Thacker, Ravi Jhaveri, Dimitri A Christakis, L Charles Bailey, Christopher B Forrest, Yong Chen
Keywords: Humans; Child; Cohort Studies; Retrospective Studies; Systemic Inflammatory Response Syndrome/diagnosis/epidemiology; Connective Tissue Diseases
Pathobiology Adult
VanElzakker, MB; Bues, HF; Brusaferri, L; et. al., bioRxiv
Information
Caution: Preprints are preliminary reports of work that have not been certified by peer review. They should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Published:
Journal: bioRxiv
Abstract: The COVID-19 pandemic caused by SARS-CoV-2 has triggered a consequential public health crisis of post-acute sequelae of COVID-19 (PASC), sometimes referred to as long COVID. The mechanisms of the heterogeneous persistent symptoms and signs that comprise PASC are under investigation, and several studies have pointed to the central nervous and vascular systems as being potential sites of dysfunction. In the current study, we recruited individuals with PASC with diverse symptoms, and examined the… Continue reading
Authors: Michael B VanElzakker, Hannah F Bues, Ludovica Brusaferri, Minhae Kim, Deena Saadi, Eva-Maria Ratai, Darin D Dougherty, Marco L Loggia
Keywords: COVID-19; Long COVID pathogenesis; brain inflammation; cardiovascular; fibrinogen; glia; microglia; neuroimaging; positron emission tomography
EHR Adult
Hill, EL; Mehta, HB; Sharma, S; et. al., BMC Public Health
Published:
Journal: BMC Public Health
Abstract: More than one-third of individuals experience post-acute sequelae of SARS-CoV-2 infection (PASC, which includes long-COVID). The objective is to identify risk factors associated with PASC/long-COVID diagnosis. This was a retrospective case-control study including 31 health systems in the United States from the National COVID Cohort Collaborative (N3C). 8,325 individuals with PASC (defined by the presence of the International Classification of Diseases, version 10 code U09.9 or a long-COVID… Continue reading
Authors: Elaine L Hill, Hemalkumar B Mehta, Suchetha Sharma, Klint Mane, Sharad Kumar Singh, Catherine Xie, Emily Cathey, Johanna Loomba, Seth Russell, Heidi Spratt, Peter E DeWitt, Nariman Ammar, Charisse Madlock-Brown, Donald Brown, Julie A McMurry, Christopher G Chute, Melissa A Haendel, Richard Moffitt, Emily R Pfaff, Tellen D Bennett; N3C Consortium; RECOVER Consortium
Keywords: COVID-19; Long-COVID; PASC; Post-acute sequelae of SARS-CoV-2; Risk factors
EHR Adult
Summary
L Mandel, H; Colleen, G; Abedian, S; et. al., Sleep
Published:
Journal: Sleep
Abstract: Study objectives: Obstructive sleep apnea (OSA) has been associated with more severe acute coronavirus disease-2019 (COVID-19) outcomes. We assessed OSA as a potential risk factor for Post-Acute Sequelae of SARS-CoV-2 (PASC). Methods: We assessed the impact of preexisting OSA on the risk for probable PASC in adults and children using electronic health record data from multiple research networks. Three research networks within the REsearching COVID to Enhance Recovery initiative (PCORnet… Continue reading
Authors: Hannah L Mandel, Gunnar Colleen, Sajjad Abedian, Nariman Ammar, L Charles Bailey, Tellen D Bennett, M Daniel Brannock, Shari B Brosnahan, Yu Chen, Christopher G Chute, Jasmin Divers, Michael D Evans, Melissa Haendel, Margaret A Hall, Kathryn Hirabayashi, Mady Hornig, Stuart D Katz, Ana C Krieger, Johanna Loomba, Vitaly Lorman, Diego R Mazzotti, Julie McMurry, Richard A Moffitt, Nathan M Pajor, Emily Pfaff, Jeff Radwell, Hanieh Razzaghi, Susan Redline, Elle Seibert, Anisha Sekar, Suchetha Sharma, Tanayott Thaweethai, Mark G Weiner, Yun Jae Yoo, Andrea Zhou, Lorna E Thorpe
Keywords: Chronic COVID-19 Syndrome; Late sequelae of COVID-19; Long COVID; Long haul COVID-19; Long-term COVID-19; Obstructive; Post COVID-19 syndrome; Post-acute COVID-19; Post-acute sequelae COVID-19; Post-acute sequelae of SARS-CoV-2 infection; Sleep Apnea
Short Summary

Researchers wanted to see if patients who had difficulty breathing while sleeping (Obstructive Sleep Apnea; OSA) were at higher risk for developing Long COVID compared to people without OSA. By comparing the electronic health record (EHR) data of COVID positive patients, researchers looked at the risk of developing Long COVID in patients with and without a previous diagnosis of OSA.

Researchers found that adults with a previous diagnosis of OSA had an increased chance of developing Long COVID when compared to patients that did not have a previous diagnosis of OSA.

Pathobiology Adult
Klein, J; Wood, J; Jaycox, J; et. al., Nature
Information
Epub ahead of print indicates that the article has completed the peer review process and has been published online in advance of the actual print journal issue being released.
Published:
Journal: Nature
Abstract: Post-acute infection syndromes (PAIS) may develop after acute viral disease. Infection with SARS-CoV-2 can result in the development of a PAIS known as "Long COVID" (LC). Individuals with LC frequently report unremitting fatigue, post-exertional malaise, and a variety of cognitive and autonomic dysfunctions; however, the biological processes associated with the development and persistence of these symptoms are unclear. Here, 273 individuals with or without LC were enrolled in a cross-sectional… Continue reading
Authors: Jon Klein, Jamie Wood, Jillian Jaycox, Rahul M Dhodapkar, Peiwen Lu, Jeff R Gehlhausen, Alexandra Tabachnikova, Kerrie Greene, Laura Tabacof, Amyn A Malik, Valter Silva Monteiro, Julio Silva, Kathy Kamath, Minlu Zhang, Abhilash Dhal, Isabel M Ott, Gabrielee Valle, Mario Peña-Hernandez, Tianyang Mao, Bornali Bhattacharjee, Takehiro Takahashi, Carolina Lucas, Eric Song, Dayna Mccarthy, Erica Breyman, Jenna Tosto-Mancuso, Yile Dai, Emily Perotti, Koray Akduman, Tiffany J Tzeng, Lan Xu, Anna C Geraghty, Michelle Monje, Inci Yildirim, John Shon, Ruslan Medzhitov, Denyse Lutchmansingh, Jennifer D Possick, Naftali Kaminski, Saad B Omer, Harlan M Krumholz, Leying Guan, Charles S Dela Cruz, David van Dijk, Aaron M Ring, David Putrino, Akiko Iwasaki
Keywords: Not available
Review Adult
Summary
Kim, C; Chen, B; Mohandas, S; et. al.RECOVER Mechanistic Pathways Task ForceRECOVER Initiative, eLife
Published:
Journal: eLife
Abstract: The NIH-funded RECOVER study is collecting clinical data on patients who experience a SARS-CoV-2 infection. As patient representatives of the RECOVER Initiative's Mechanistic Pathways task force, we offer our perspectives on patient motivations for partnering with researchers to obtain results from mechanistic studies. We emphasize the challenges of balancing urgency with scientific rigor. We recognize the importance of such partnerships in addressing post-acute sequelae of SARS-CoV-2 infection… Continue reading
Authors: C Kim, Benjamin Chen, Sindhu Mohandas, Jalees Rehman, Zaki A Sherif, K Coombs, ,
Keywords: advocacy; epidemiology; global health; lived experience; long COVID; mechanistic pathways; patient-centered; patient-partnered; post-acute sequelae of SARS-CoV-2 (PASC)
Short Summary

Long COVID patients, caregivers, and community members contribute to all parts of RECOVER, including scientific research. These chosen members of the community are known as RECOVER Representatives. This paper, written by a team of RECOVER Representatives and researchers, talks about why they chose to work together and how their partnership has improved the study. They summarize some of the impacts of Long COVID and highlight the roles that patient advocacy can play in research. They also discuss what progress has been made so far in studying Long COVID and what challenges lie ahead. The authors state that the result of Representatives working together with researchers on study design, ways to include patients, and sharing community concerns has set a new example for the design of future biomedical research studies.

EHR Adult
Yoo, YJ; Wilkins, KJ; Alakwaa, F; et. al. N3C and RECOVER Consortia, Clinical Journal of the American Society of Nephrology
Published:
Journal: Clinical Journal of the American Society of Nephrology
Abstract: AKI is associated with mortality in patients hospitalized with coronavirus disease 2019 (COVID-19); however, its incidence, geographic distribution, and temporal trends since the start of the pandemic are understudied. Electronic health record data were obtained from 53 health systems in the United States in the National COVID Cohort Collaborative. We selected hospitalized adults diagnosed with COVID-19 between March 6, 2020, and January 6, 2022. AKI was determined with serum creatinine and… Continue reading
Authors: Yun J Yoo, Kenneth J Wilkins, Fadhl Alakwaa, Feifan Liu, Luke A Torre-Healy, Spencer Krichevsky, Stephanie S Hong, Ankit Sakhuja, Chetan K Potu, Joel H Saltz, Rajiv Saran, Richard L Zhu, Soko Setoguchi, Sandra L Kane-Gill, Sandeep K Mallipattu, Yongqun He, David H Ellison, James B Byrd, Chirag R Parikh, Richard A Moffitt, Farrukh M Koraishy,
Keywords: Adult; Humans; COVID-19/complications/epidemiology; Retrospective Studies; Creatinine; Risk Factors; Acute Kidney Injury/diagnosis; Hospital Mortality
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